Emerging data connects the aging process in dermal fibroblasts with metabolic reprogramming, provided by enhanced fatty acid oxidation and reduced glycolysis. This switch may be caused by a significant expansion of the dermal white adipose tissue (dWAT) layer in aged, hair‐covered skin. Dermal adipocytes cycle through de‐differentiation and re‐differentiation. As a result, there is a strongly enhanced release of free fatty acids into the extracellular space during the de‐differentiation of dermal adipocytes in the catagen phase of the hair follicle cycle. (...) Both caveolin‐1 and adiponectin are critical factors influencing these processes. Controlling the expression levels of these two factors also offers the ability to manipulate the metabolic preferences of the different cell types within the microenvironment of the skin, including dermal fibroblasts. Differential expression of adiponectin and caveolin‐1 in the various cell types may also be responsible for the cellular metabolic heterogeneity within the cells of the skin. (shrink)

Quality of life is an important outcome measure in mental health care. Currently, QoL is mainly measured with paper and pencil questionnaires. To contribute to the evaluation of treatment, and to enhance substantiated policy decisions in the allocation of resources, a web-based, personalized, patient-friendly and easy to administer QoL instrument has been developed: the QoL-ME. While human values play a significant role in shaping future use practices of technologies, it is important to anticipate on them during the design of the (...) QoL-instrument. The value sensitive design approach offers a theory and method for addressing these values in a systematic and principled manner in the design of technologies. While the VSD approach has been applied in the field of somatic care, we extended the VSD approach to the field of mental healthcare with the aim to enable developers of the QoL-instrument to reflect on important human values and anticipate potential value conflicts in its design. We therefore explored how VSD can be used by investigating the human values that are relevant for the design of the QoL-ME. Our exploration reveals that the values autonomy, efficiency, empowerment, universal usability, privacy, redifinition of roles, of responsibilites, reliability, solidarity, surveillance and trust are at stake for the future users of the technology. However, we argue that theoretical reflections on the potential ethical impact of a technology in the design phase can only go so far. To be able to comprehensively evaluate the usability the VSD approach, a supplementary study of the use practices of the technology is needed. (shrink)

Odor and color are strongly associated. Numerous studies demonstrate consistent odor‐color associations, as well as effects of color on odor perception and language. Yet, we know little about how these associations arise. Here, we test whether language is a possible mediator of odor‐color associations, specifically whether odor‐color associations are mediated by implicit odor naming. In two experiments, we used an interference paradigm to prevent the verbalization of odors during an odor‐color matching task. If participants generate color associations subsequent to labeling (...) an odor, interfering with verbalization during the task should affect the ability to make color associations. In Experiment 1, contrary to our hypothesis, verbal interference did not affect odor‐color matches. However, since performance accuracy on the verbal interference task was high, it is possible our task did not sufficiently disrupt verbal processing. In Experiment 2, we, therefore, used an active verbal interference task, and still found no difference across interference conditions. Odor naming accuracy, odor familiarity, and odor pleasantness, however, did predict odor‐color matches. This suggests that although color associations are related to semantic factors, they are not generated by recruiting odor labels in the moment. Overall, our results do not provide evidence that language plays an online role in odor‐color associations, instead, they are consistent with the claim that language may have shaped associations during development. (shrink)

Although taste and smell seem hard to imagine, some people nevertheless report vivid imagery in these sensory modalities. We investigate whether experts are better able to imagine smells and tastes because they have learned the ability, or whether they are better imaginers in the first place, and so become experts. To test this, we first compared a group of wine experts to yoked novices using a battery of questionnaires. We show for the first time that experts report greater vividness of (...) wine imagery, with no difference in vividness across sensory modalities. In contrast, novices had more vivid color imagery than taste or odor imagery for wines. Experts and novices did not differ on other vividness of imagery measures, suggesting a domain‐specific effect of expertise. Critically, in a second study, we followed a group of students commencing a wine course and a group of matched control participants. Students and controls did not differ before the course, but after the wine course students reported more vivid wine imagery. We provide evidence that expertise improves imagery, exemplifying the extent of plasticity of cognition underlying the chemical senses. (shrink)

Razprava se ukvarja z analizo prvega pisma iz Hieronimove korespondence. Avtor je imel do njega očitno ambivalenten odnos, kar kliče k iskanju večplastne sporočilnosti spisa. Po poskusu datacije, retorični in slogovni analizi ter predstavitvi osnovne zgodbe, ki je vključena vanj, se pokaže, da je pismo kljub navidezni hagiografski šablonskosti vsebinsko bogato. Analiza se zato nadaljuje na dveh področjih. Kraj dogajanja, poznoantično mesto, ne more preživeti brez nove vodilne osebnosti, škofa. Je s pismom Hieronim želel tlakovati pot na vercelski škofovski sedež (...) prijatelju Evagriju iz Antiohije? Ob analizi nejasnih spolnih identitet obeh glavnih oseb iz zgodbe, nemoškega mladeniča in moško neuklonljive ženske, se pokaže, da je Hieronim v novem času iskal nov krščanski ideal, meništvo, ki ga je preko te zgodbe umestil v kontinuiteto z mučeništvom. (shrink)

Knjiga, ki ji je posvečena pričujoča recenzija, prinaša prevod dveh krajših Bonaventurovih del, O trojni poti (De triplici via) in Kako se različne umetnosti zvajajo na teologijo (De reductione artium ad theologiam). Prevedla ju je filozofinja in klasična filologinja Nena Bobovnik, ki na KU Leuven pripravlja doktorat iz srednjeveške filozofije. Poleg spremne besede z naslovom »Zaris srednjeveške in skicaBonaventurove filozofije« sta še dva uvoda v piščevo misel. Najprej tri kateheze, ki jih je papež Benedikt XVI. – ki se je na (...) Bonaventurovo teologijo zgodovine osredotočil v habilitacijski nalogi – spomladi leta 2010 posvetil svojemu »prijatelju«, kot se sam izrazi; nato pa še esej »Teološko-filozofska hermenevtika pri sv. Bonaventuru in njen pomen za današnji čas«, ki ga je pripravil Branko Klun s Teološke fakultete UL. (shrink)

Religion and violence are related in an ambivalent, paradoxical way, for the systems of religious knowledge tend to prohibit violence and to motivate it at the same time. This paper looks for the roots of that ambivalence and reveals particular mechanisms that generate violence within religious systems and their associated practices. It argues that violence in religious systems is present in at least three forms: It is inherent to communication with the “sacred,” it is generated by processes of inclusion and (...) exclusion, shaping religiously interpreted lifeworlds, and it is motivated or moderated by the respective semantics of religious narratives. The paper concludes that violence as a moment of hierophany is constitutive for the living experience in religious systems and cannot be eliminated entirely by moderating semantics. (shrink)

An awareness of the special role of the time factor in the organization and functioning of living systems and achievements in the study of biological clocks have posed the problem of the role of the time factor in relation to the whole concept of reflection of reality. The study of this role is one of the extremely timely and fundamental tasks of scientific theory. The problem of "reflection and time" has essentially become one of the main lines of general theoretical (...) attempts to understand the structure of space and time and the unity of the world, the principle of the universal interrelatedness and mutual dependence among objects and phenomena, and the essence of the reflective activity of living systems. (shrink)

In the first section of this contribution, three conditions for scientific research into answers to fundamental, existential questions are discussed. However, because these conditions seem to violate concepts such as 'intersubjectivity' and 'truth', the second section deals with the question in which way a scientific approach that satisfies these three conditions can still be called scientific. The 'possibilistic scientific view' that results from this investigation, will in the third section be exemplified by qualitative research. It will be demonstrated that this (...) social scientific approach can meet the three aforementioned conditions. In the last section, one of the features of such a qualitative approach will be emphasized. 'Radical subjectivity' will be presented as a way to fully satisfy the third condition of research into questions of meaning. (shrink)

Mit der Entstehung der Collage wurde eine Kulturrevolution in Gang gesetzt, die sich heute in vielen einzelnen Verästelungen zeigt und die dazu geführt hat, dass man die Kunst mit anderen Augen sehen muss. Das Urheberrecht hat nach wie vor in vielen Teilen auf diese kulturelle Bewegung nicht reagiert. Dies erkennend, hat es sich die vorliegende Dissertation zum Ziel gesetzt, einzelne urheberrechtliche Problemschwerpunkte am konkreten Beispiel der Collage zu diskutieren. So werden u.a. Fragen nach einem zeitgenössischen Werkbegriff, nach dem richtigen Umgang (...) mit der erlaubnisfreien Nachschöpfung durch Dritte sowie der Urheberpersönlichkeitsrechte aufgegriffen. Dabei wird eine grundlegende Betrachtung vorgenommen, deren Grundsätze nicht alleine auf den Umgang mit der Collage beschränkt sind, sondern deren Aussagekraft von zukunftweisender Natur sind. Denn gerade mit Blick auf die zunehmende Technologisierung der Mittel, die es Jedermann erlaubt, unter Zuhilfenahme von vorgefundenem, urheberrechtlich geschützten Material tätig zu werden, wachsen die angesprochenen Probleme weiter und stellen das Urheberrecht, mehr noch als das heute der Fall ist, vor große Herausforderungen und Belastungen. (shrink)

Can a phenomenologically-founded sociology contribute to the understanding of social change? By reference to the structure of the lifeworld as it has been analyzed by Husserl and Schutz, I argue that human action is formed by temporal, spatial, and social dimensions. These are objectified by a social semantics through which they gain their intersubjective cultural shape. From this perspective, I investigate changes in the temporal, spatial, and social dimensions of this semantics, as they occur in the present transformation of post-socialist (...) societies. Finally, I consider whether these changes mark a return to Western patterns and whether they confirm the thesis of the end of history. (shrink)

Denys Page, discussing this poem in his classic Sappho and Alcaeus, seemed unimpressed by its aesthetic merits. In his note on line 7 he says: ‘The sequence of thought might have been clearer.... It seems then inelegant to begin this parable, the point of which is that Helen found O Krλλιστον in her lover, by stating that she herself surpassed all mortals in this very quality’ . His interpretative essay phrases further objections. ‘In a phrase which rings dull in our (...) doubtful ears, she proceeds to illustrate the truth of her preamble by calling Helen of Troy in evidence’ . About the Helen exemplum itself he says: ‘the thought is simple as the style is artless’ and ‘the transition back to the principal subject was perhaps not very adroitly; managed’ . Page's criticism centres on the function of the exemplum of Helen. A close reconsideration of this exemplum, with special attention to the way in which it is embedded in the preceding and following context, will result in a better understanding and appreciation of this poem. (shrink)

Just about every odd year in the early fifth century B.C. has been proposed as the date of the Nemean victory of Pytheas from Aegina, celebrated in Pindar's Fifth Nemean and Bacchylides' thirteenth ode. Scholars have attempted to date both odes with the help of Isthmian 6 and 5, which celebrate victories of a member of the same family and the latter of which at 48ff. refers to Salamis as a recent event. Various interpretations of the victory catalogues in I. (...) 6 and 5 have led to various dates for N. 5 and B. 13. The fullest analysis of the material is that by Severyns, who argues that N. 5 and B. 13 must be at least seven years earlier than I. 5. In his conclusion , however, he still suggests three possible dates for N. 5 and B. 13: 487, 489, and 485 B.C., in what he considers to be the order of likelihood. (shrink)

Every time we look around we can see a rich and detailed world surrounding us. Nevertheless, the majority of visual information seems to slip out of our thoughts instantly. Can we still say that this fleeting percept of the entire world was a conscious percept in the first place, as Block proposes?

Moral philosophers agree that welfare matters. But they disagree about what it is, or how much it matters. In this vital new work, Wayne Sumner presents an original theory of welfare, investigating its nature and discussing its importance. He considers and rejects all notable theories of welfare, both objective and subjective, including hedonism and theories founded on desire or preference. His own theory connects welfare closely with happiness or life satisfaction. Reacting against the value pluralism that currently dominates moral philosophy, (...) he advances welfare as the only basic ethical value. He concludes by discussing the implications of this thesis for ethical and political theory. Written in clear, non-technical language, and including a definitive survey of other work in this area, Sumner's book is essential reading for moral philosophers, political theorists, and welfare economists. (shrink)

Der Band dokumentiert das breite Spektrum der phänomenologischen Forschung in der gegenwärtigen soziologischen Landschaft. Er präsentiert die Weiterentwicklung des phänomenologischen Ansatzes in den Bereichen der Theorie, der Methoden sowie der empirischen Untersuchungen.

This book closely examines our commonly held beliefs about human suffering, and offers unique insights into God's role in why we suffer. Dr. Perri critically examines what it means to be human from a Judeo-Christian perspective, and extrapolates from the work of Carl Gustav Jung showing a deeply complex development of human transcendence in human suffering. On an interpersonal level, Dr. Perri elaborates on the work of Martin Buber and Emanuel Levinas and shows how our suffering can be shared and (...) lessened by our unconditionality and presence for the other. Scriptural passages are quoted from both the Hebrew and New Testament texts, and are used to depict the suffering of humankind as seen in the face of Job. It was this face, according to Perri, that Jesus saw in the faces of those He came to redeem, and that ultimately brought Him to the crucifix of redemption. Dr. Perri challenges Sartre's position that our existence precedes our essence, and draws on the work of Abraham Joshua Heschel and Christian theology in this regard. He further elaborates a neurodevelopmental paradigm that creates essence as the basis of our freedom to choose. This book can be read and studied by both professionals in the helping and healing professions, and lay persons seeking to better understand our suffering, and how to better help those who suffer. Dr. Perri offers specific ways in how to be present for those who suffer, how to read and receive the hidden language of human suffering, and how to use silence as a communication skill. (shrink)